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Inflammatory Myositis Treatment in Nagpur

Inflammatory Myositis

Inflammatory myositis refers to a group of rare autoimmune disorders characterized by inflammation and weakness in the skeletal muscles. These conditions are caused by the immune system mistakenly attacking healthy muscle tissue, leading to muscle damage and dysfunction. Inflammatory myositis encompasses several subtypes, including dermatomyositis, polymyositis, and inclusion body myositis.

Types of Inflammatory Myositis:

Dermatomyositis: Dermatomyositis is characterized by muscle weakness and a distinctive skin rash. The rash often appears on the face (in the form of a “heliotrope” rash), eyelids, elbows, knees, and knuckles. Skin changes may include red or purple discoloration, scaling, and thickening.

Polymyositis: Polymyositis primarily affects the muscles, causing weakness, pain, and fatigue. Unlike dermatomyositis, polymyositis does not typically involve prominent skin manifestations. It mainly affects the proximal muscles (those closest to the trunk), such as the shoulders, hips, thighs, and upper arms.

Inclusion Body Myositis (IBM): Inclusion body myositis is characterized by progressive muscle weakness and atrophy, particularly in the distal muscles (those farther from the trunk) of the arms and legs. IBM is distinct from other forms of inflammatory myositis due to the presence of characteristic inclusion bodies within muscle cells.

Causes of Inflammatory Myositis:

The exact cause of inflammatory myositis is not fully understood, but it is believed to involve a combination of genetic predisposition, environmental triggers, and abnormal immune responses. Factors that may contribute to the development of inflammatory myositis include viral infections, exposure to certain medications, genetic susceptibility, and other autoimmune diseases.

Common symptoms of inflammatory myositis include:
  • Muscle weakness, particularly in the proximal muscles (shoulders, hips)
  • Muscle pain and tenderness
  • Fatigue and malaise
  • Difficulty swallowing (dysphagia), in some cases
  • Skin changes, such as rash and skin lesions (in dermatomyositis)
  • Systemic symptoms, including fever, weight loss, and joint pain
Diagnosis of Inflammatory Myositis:

Diagnosis of inflammatory myositis involves a combination of clinical evaluation, laboratory tests, electromyography (EMG), muscle biopsy, and imaging studies. Blood tests may reveal elevated levels of muscle enzymes, such as creatine kinase (CK), and autoimmune antibodies. Electromyography evaluates muscle function and nerve activity, while muscle biopsy examines tissue samples for signs of inflammation and characteristic features of myositis.

Treatment of Inflammatory Myositis:

Treatment aims to reduce inflammation, alleviate symptoms, and prevent disease progression. Pharmacological interventions may include corticosteroids to suppress immune activity, immunosuppressants (such as methotrexate or azathioprine) for long-term management, and other medications to manage associated symptoms or complications. Physical therapy and occupational therapy can help maintain muscle strength, mobility, and function. Regular medical follow-ups are essential for monitoring disease activity and adjusting treatment as needed.

In summary, inflammatory myositis is a group of autoimmune disorders characterized by muscle inflammation and weakness. While these conditions can significantly impact quality of life, early diagnosis and appropriate treatment can help manage symptoms and improve outcomes for affected individuals.

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